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2021;62:e3739

The interactions between drugs and disease targets were visualized using Venny 2.1 to generate a Venn diagram, revealing 17 drug-disease targets (Figure 5C)

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The diet must also include non-digestible components, particularly dietary fibers, in addition to the necessary nutrients, including proteins, vitamins, lipids, and minerals, as diet strongly influences the composition of colonic microbiota and their metabolic products (2)

The metabolic heterogeneity of diverse tumor types, varied clinical stages, distinct cell populations within the TME may be one of the factors contributing to the poor efficacy of metabolic-targeted drugs